Symptoms and Treatments of Buruli ulcer - Mycobacterium ulcerans infection

Buruli ulcer (Mycobacterium ulcerans infection)

Symptoms of Buruli ulcer begin with painless nodules and swelling, usually on the arms and legs and sometimes on other parts of the body. 

Buruli ulcer is a terrible chronic condition that primarily affects the skin and occasionally the bones. Sir Albert Cook first reported the bacterium in Uganda in 1897, but it wasn't until the 1930s that Australian scientists led by Peter MacCallum were able to culture it from lesions of patients from the Bairnsdale region. Buruli is named after a region in Uganda where many instances were reported in the 1960s. Children under the age of 15 make up roughly half of the patients in Africa. The average age in Australia is roughly 60 years. In response to the disease's rising spread, notably in West Africa, WHO developed the Global Buruli Ulcer Initiative in 1998.

Buruli ulcer is caused by Mycobacterium and belongs to the family of bacteria that causes tuberculosis and leprosy. Although the causative organism of Buruli ulcer is an environmental bacterium, the mode of transmission to humans remains unknown. The organism produces a unique toxin – mycolactone – that causes damage to the skin. Early diagnosis and treatment are crucial to minimizing morbidity, costs and prevent long-term disability. 

Symptoms of Buruli ulcer begin with painless nodules and swelling, usually on the arms and legs and sometimes on other parts of the body. These areas can then develop into large ulcers with a white and yellow base. M. ulcerans produces the toxin mycolactone. This has local immunosuppressive properties that enable the disease to progress rapidly with no pain and fever, making early detection difficult. However, if the ulcers are treated quickly, most will heal completely. 

If diagnosed late or left untreated, the condition can lead to scarring, permanent disfigurement, and disability.   

Buruli ulcer has been reported in 33 countries in Africa, the Americas, Asia and the Western Pacific. Most cases occur in tropical and subtropical regions except in Australia, China, and Japan. Out of the 33 countries, 14 regularly report data to WHO. The annual number of suspected Buruli ulcer cases reported globally was around 5000 cases until 2010, when it started to decrease until 2016, reaching its minimum of 1961 cases reported. Since then, the the number of cases has started to rise again every year up to 2713 cases in 2018. The reasons for the decline and for the recent increase are not clear.

Treatment consists of a combination of antibiotics and complementary treatments (under morbidity management and disability prevention/rehabilitation). 

Antibiotics:

Current WHO recommendations are rifampicin 10 mg/kg per body weight daily and clarithromycin 7.5 mg/kg per body weight twice daily. Treatment guidance for health workers can be found in the WHO publication Treatment of mycobacterium ulcerans disease (Buruli ulcer).

Other interventions

In addition to the antibiotics and depending on the stage of the disease, other interventions such as wound care, lymphoedema management, surgery (mainly debridement and skin grafting to speed up healing), and physiotherapy are needed. Psychological support may also be needed for those with severe disease.

These same interventions are applicable to other neglected tropical diseases, such as leprosy and lymphatic filariasis, so it is important to integrate a long-term care approach into the health system to benefit all patients. The integrated approach to the control of skin-related NTDs provides an opportunity to integrate Buruli ulcer detection and its management with these diseases.